Publications

Watson JA, Pantier R, Jayachandran U, Chhatbar K, Alexander-Howden B, Kruusvee V, Prendecki M, Bird A, Cook AG (2022) bioRxiv 2022.06.14.495968; doi: https://doi.org/10.1101/2022.06.14.495968

Haque N, Will A, Cook AG, Hogg JR (2022) A network of DZF proteins controls alternative splicing regulation and fidelity bioRxiv 2022.06.15.495552; doi: https://doi.org/10.1101/2022.06.15.495552

Deák G and Cook AG (2022) Missense Variants Reveal Functional Insights Into the Human ARID Family of Gene Regulators JMB 434(9):167529. doi: 10.1016/j.jmb.2022.167529 PMID: 35257783

Bayne RA, Jayachandran U, Kasprowicz A, Bresson S, Tollervey D, Wallace EWJ, Cook AG (2021) Yeast Ssd1 is a non-enzymatic member of the RNase II family with an alternative RNA recognition interface. Nucleic Acids Research, DOI: 10.1093/nar/gkab615.

Pantier P, Chhatbar K, Quante T, Skourti-Stathaki K, Cholewa-Waclaw J, Alston G, Alexander-Howden B, Lee HY, Cook AG, Spruijt CG, Vermeulen M, Selfridge J, Bird A (2021) SALL4 controls cell fate in response to DNA base composition. Molecular Cell 2021 81:845–858.e8. doi: 10.1016/j.molcel.2020.11.046

Ballou ER, Cook AG, Wallace EWJ (2021) Repeated evolution of inactive pseudonucleases in a fungal branch of the Dis3/RNase II family of nucleases. Molecular Biology and Evolution 2021 38: 1837–1846. doi: 10.1093/molbev/msaa324

Zoch A, Auchynnikava T, Berrens RV, Kabayama Y, Schöpp T, Heep M, Vasiliauskaitė L, Pérez-Rico YA, Cook AG, Shkumatava A, Rappsilber J, Allshire RC and O’Carroll D (2020) SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation. Nature 584:635-639 doi: 10.1038/s41586-020-2557-5

Kruusvee V§, Lyst MJ§, Taylor C, Tarnauskaitė Ž, Bird AP$ and Cook AG$ (2017) Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders. PNAS  114:E3243-E3250. doi: 10.1073/pnas.1700731114 $Joint corresponding, § joint first author

Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases.  McCaughan UM, Jayachandran U, Shchepachev V, Chen ZA, Rappsilber J, Tollervey D, Cook AG. (2016) Nat Commun. 7:11789 doi: 10.1038/ncomms11789. PMID: 27250689

Nuclear factor 90 uses an ADAR2-like binding mode to recognize specific bases in dsRNA.   Jayachandran U, Grey H, Cook AG.  Nucleic Acids Res. (2015)  doi: 10.1093/nar/gkv1508  PMID:26712564

The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology.  Wandrey F, Montellese C, Koos K, Badertscher L, Bammert L, Cook AG, Zemp I, Horvath P, Kutay U. Mol Cell Biol. (2015) 35:3491-503. doi: 10.1128/MCB.00306-15.

Snapshots of pre-rRNA structural flexibility reveal eukaryotic 40S assembly dynamics at nucleotide resolution. Hector RD, Burlacu E, Aitken S, Le Bihan T, Tuijtel M, Zaplatina A, Cook AG, Granneman S. Nucleic Acids Res. (2014) 42:12138-54. doi: 10.1093/nar/gku815.

NF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltranserase fold. Wolkowicz UM and Cook AG Nucleic Acids Research (2012) PMID: 22833610

Nuclear export complexes in the frame. Cook AG, Conti E. Curr Opin Struct Biol. (2010) 20:247-52 Review.

Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13. Bono F, Cook AG, Grünwald M, Ebert J, Conti E. Mol Cell. (2010) 37:211-22.

Structures of the tRNA export factor in the nuclear and cytosolic states. Cook AG, Fukuhara N, Jinek M, Conti E. Nature. (2009) 461:60-5.

Structural biology of nucleocytoplasmic transport. Cook A, Bono F, Jinek M, Conti E. Annu Rev Biochem. (2007) 76:647-71. Review.

The structure of the nuclear export receptor Cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding. Cook A, Fernandez E, Lindner D, Ebert J, Schlenstedt G, Conti E. Mol Cell. (2005) 18:355-67.

Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide. Cook AG, Johnson LN, McDonnell JM. FEBS J. (2005) 272:1511-22.

The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. Honda R, Lowe ED, Dubinina E, Skamnaki V, Cook A, Brown NR, Johnson LN. EMBO J. (2005) 24:452-63

Structural studies on phospho-CDK2/cyclin A bound to nitrate, a transition state analogue: implications for the protein kinase mechanism. Cook A, Lowe ED, Chrysina ED, Skamnaki VT, Oikonomakos NG, Johnson LN. Biochemistry (2002) 41:7301-11.

Structure of human transthyretin complexed with bromophenols: a newmode of binding. Ghosh M, Meerts IA, Cook A, Bergman A, Brouwer A, Johnson LN. Acta Crystallographica D (2000) 56:1085:95