Publications

Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases.  McCaughan UM, Jayachandran U, Shchepachev V, Chen ZA, Rappsilber J, Tollervey D, Cook AG. (2016) Nat Commun. 7:11789 doi: 10.1038/ncomms11789. PMID: 27250689

Nuclear factor 90 uses an ADAR2-like binding mode to recognize specific bases in dsRNA.   Jayachandran U, Grey H, Cook AG.  Nucleic Acids Res. (2015)  doi: 10.1093/nar/gkv1508  PMID:26712564

The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology.  Wandrey F, Montellese C, Koos K, Badertscher L, Bammert L, Cook AG, Zemp I, Horvath P, Kutay U. Mol Cell Biol. (2015) 35:3491-503. doi: 10.1128/MCB.00306-15.

Snapshots of pre-rRNA structural flexibility reveal eukaryotic 40S assembly dynamics at nucleotide resolution. Hector RD, Burlacu E, Aitken S, Le Bihan T, Tuijtel M, Zaplatina A, Cook AG, Granneman S. Nucleic Acids Res. (2014) 42:12138-54. doi: 10.1093/nar/gku815.

NF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltranserase fold. Wolkowicz UM and Cook AG Nucleic Acids Research (2012) PMID: 22833610

Nuclear export complexes in the frame. Cook AG, Conti E. Curr Opin Struct Biol. (2010) 20:247-52 Review.

Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13. Bono F, Cook AG, Grünwald M, Ebert J, Conti E. Mol Cell. (2010) 37:211-22.

Structures of the tRNA export factor in the nuclear and cytosolic states. Cook AG, Fukuhara N, Jinek M, Conti E. Nature. (2009) 461:60-5.

Structural biology of nucleocytoplasmic transport. Cook A, Bono F, Jinek M, Conti E. Annu Rev Biochem. (2007) 76:647-71. Review.

The structure of the nuclear export receptor Cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding. Cook A, Fernandez E, Lindner D, Ebert J, Schlenstedt G, Conti E. Mol Cell. (2005) 18:355-67.

Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide. Cook AG, Johnson LN, McDonnell JM. FEBS J. (2005) 272:1511-22.

The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. Honda R, Lowe ED, Dubinina E, Skamnaki V, Cook A, Brown NR, Johnson LN. EMBO J. (2005) 24:452-63

Structural studies on phospho-CDK2/cyclin A bound to nitrate, a transition state analogue: implications for the protein kinase mechanism. Cook A, Lowe ED, Chrysina ED, Skamnaki VT, Oikonomakos NG, Johnson LN. Biochemistry (2002) 41:7301-11.

Structure of human transthyretin complexed with bromophenols: a newmode of binding. Ghosh M, Meerts IA, Cook A, Bergman A, Brouwer A, Johnson LN. Acta Crystallographica D (2000) 56:1085:95