Structural Biology of molecular machines in eukaryotic RNA metabolism

We are interested in understanding, at a structural level, how proteins involved in RNA metabolism interact with their RNA targets and affect downstream processes. To this end, we are studying the role of several proteins that are involved in the nuclear export and maturation of eukaryotic ribosomes.

We are also interested in RNA binding proteins that affect gene expression either co- or post-transcriptionally. We have recently solved the structure of a complex of the dimerisation domain of NF90/NF45 (above). This complex is thought to be involved in regulating transcription and translation of a number of mRNA targets. The structure of the dimerisation domain reveals that NF45 is able to recognise a number of related complexes using the same molecular interface.